These medicines come in three classes: antacids, H2 blockers, and protein pump inhibitors PPIs . Pregnancy tends to aggravate heartburn. The symptoms of GORD can sometimes return after a course of PPIs has been Cure for heartburn and upset stomach Stop smoking. Lose weight. indigestion and acid reflux are common in pregnancy. Fennel contains chemicals that may make your womb uterus contract. Bernstein Test. Pregnancy tends to aggravate heartburn.