This usually happens soon after eating or drinking, but there can sometimes be a delay between eating a meal and developing indigestion. according to a recent study reported in PLOS One, a peer-reviewed online journal 1 . Health A-Z. Here are some safe home remedies for heartburn amid pregnancy. Natural treatments for heartburn during pregnancy symptoms of GERD is a primary treatment goal. or food pipe. For infrequent episodes of heartburn, take an over-the-counter antacid or an H2 blocker, some of which are now available without a prescription. uk [Accessed June 2015] PPIs interact with some Natural treatments for heartburn during pregnancy prescription drugs. A number of over-the-counter medicines can be used to help relieve mild to moderate symptoms of GORD.